4-Chloro-2-methylthiopyrimidine

  • CAS：49844-90-8
  • purity：99%
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1.What is the 4-Chloro-2-methylthiopyrimidine ?

4-Chloro-2-methylthiopyrimidine was used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It was used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors. It was used as building block in medicinal chemistry synthesis.

2-Methylthiouracil
5751-20-2,124700-69-2

2-Methylthiouracil

4-Chloro-2-methylthiopyrimidine
49844-90-8

4-Chloro-2-methylthiopyrimidine

Conditions
Conditions Yield
With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 40 ℃; for 3h;
87.6%
With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 40 ℃; for 3h;
87.6%
With trichlorophosphate;
With trichlorophosphate;
2-(methylsulfanyl)pyrimidin-4-ol
5751-20-2,124700-70-5

2-(methylsulfanyl)pyrimidin-4-ol

4-Chloro-2-methylthiopyrimidine
49844-90-8

4-Chloro-2-methylthiopyrimidine

Conditions
Conditions Yield
2-(methylsulfanyl)pyrimidin-4-ol; With trichlorophosphate; In N,N-dimethyl-formamide; toluene; at 20 ℃; for 0.5h;
With thionyl chloride; In N,N-dimethyl-formamide; toluene; at 20 - 80 ℃; for 1h; Time; Solvent; Reagent/catalyst;
88.3%
With trichlorophosphate; at 80 ℃;
With trichlorophosphate; In neat (no solvent); at 80 ℃; for 7h; Inert atmosphere;

2.What is the CAS number for 4-Chloro-2-methylthiopyrimidine ?

The CAS number of 4-Chloro-2-methylthiopyrimidine is 49844-90-8.

More information of 4-Chloro-2-methylthiopyrimidine 49844-90-8 are:

CAS?Number

49844-90-8

Density

1.37 g/cm3

Melting Point

-2 °C(lit.)

Boiling Point

243.1 °C at 760 mmHg

Flash Point

100.8 °C

Vapor Pressure

0.0511mmHg at 25°C

Refractive Index

n20/D 1.6(lit.)

HS CODE

29335990

PSA

51.08000

LogP

1.85190

Pka

-0.56±0.20(Predicted)

3.What are another words for 4-Chloro-2-methylthiopyrimidine ?

Synonyms?for?4-Chloro-2-methylthiopyrimidine 49844-90-8:2-(Methylthio)-4-chloropyrimidine;4-Chloro-2-(methylmercapto)pyrimidine;4-Chloro-2-(methylsulfanyl)pyrimidine;4-Chloro-2-(methylthio)pyrimidine;6-Chloro-2-methylthiopyrimidine;NSC 100866;

4.What is the molecular formula of 4-Chloro-2-methylthiopyrimidine?

The chemical formula of ?4-Chloro-2-methylthiopyrimidine is?C5H5ClN2S which containing 5 Carbon atoms,5 Hydrogen atoms,1 Chlorine atoms,2 Nitrogen atoms and 1 Sulfur atoms,and the molecular weight of??4-Chloro-2-methylthiopyrimidine?is 160.627.

5.What is 4-Chloro-2-methylthiopyrimidine (49844-90-8) used for?

4-Chloro-2-methylthiopyrimidine is an organic compound with the chemical formula C5H5ClN2S. It is a clear yellow to brown liquid and serves as a crucial building block in the field of medicinal chemistry synthesis.

InChI:InChI=1/C5H5ClN2S/c1-9-5-7-3-2-4(6)8-5/h2-3H,1H3

Relevant articles related to 4-Chloro-2-methylthiopyrimidine:

Article

Source

A new route for the synthesis of Palbociclib

Li, Shu-ting,Chen, Jun-qing,Feng, Cheng-liang,Yang, Wan-feng,Ji, Min

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Synthesis of N,N-dialkyl-1-(2-alkylthiopyrimidin-4-yl)piperidin- 4-amines as potential heat shock protein inhibitors

Aldobaev,Prezent,Zavarzin

, p. 2127 - 2130 (2019/01/08)

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