Details
Factory supply ISATIN-3-OXIME 607-28-3 with sufficient production capacity
- Molecular Formula: C8H6N2O2
- Molecular Weight: 162.148
- Vapor Pressure: 4.43E-08mmHg at 25°C
- Melting Point: 228°C (dec.)
- Refractive Index: 1.706
- Boiling Point: 400.5 °C at 760 mmHg
- PKA: 9.19±0.20(Predicted)
- Flash Point: 196 °C
- PSA： 61.69000
- Density: 1.49 g/cm3
- LogP: 0.95500
ISATIN-3-OXIME(Cas 607-28-3) Usage
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General Description |
ISATIN-3-OXIME is a chemical compound known for its versatile biological activities. It's an oxime derivative of the indole compound Isatin, a strong and versatile pharmacophore that can form the basis for a wide range of biologically active compounds. It is often used as a synthon in organic chemistry due to its ease of modification. In terms of medical and pharmaceutical applications, ISATIN-3-OXIME, like other Isatin derivatives, has shown potential anti-bacterial, anti-cancer, anti-convulsant and anti-viral activities. However, further studies are required to fully uncover its potential therapeutic applications. |
InChI:InChI=1/C8H6N2O2/c11-8-7(10-12)5-3-1-2-4-6(5)9-8/h1-4,12H,(H,9,10,11)
607-28-3 Relevant articles
Molecular modeling and in vitro studies of a neutral oxime as a potential reactivator for acetylcholinesterase inhibited by paraoxon
de Paula, Reuel L.,de Almeida, Joyce S.F.D.,Cavalcante, Samir F.A.,Gon?alves, Arlan S.,Simas, Alessandro B.C.,Franca, Tanos C.C.,Valis, Martin,Kuca, Kamil,Nepovimova, Eugenie,Granjeiro, José M.
, (2018)
The present work aimed to compare the sm...
Pronounced ionic liquid effect in the synthesis of biologically active isatin-3-oxime derivatives under acid catalysis
Pinto, Angelo C.,Lapis, Alexandre A. Moreira,da Silva, Barbara Vasconcellos,Bastos, Renato S.,Dupont, Ja?rton,Neto, Brenno A.D.
, p. 5639 - 5641 (2008)
An efficient method was developed for th...
The benzonitrile derivative
-
Paragraph 0048-0049, (2021/10/08)
[A] suppressing the generation of impuri...
Synthesis and evaluation of isatin derivatives as antifungal agents
Dawar, Monika,Kaur, Komalpreet,Rani, Ritu,Utreja, Divya
, p. 199 - 205 (2020/02/29)
Various types of isatin derivatives were...
1,3-Dipolar Cycloaddition of 3-Amino Oxindole-Based Azomethine Ylides and O-Vinylphosphonylated Salicylaldehydes for Diastereoselective Synthesis of Oxindole Spiro-P, N-polycyclic Heterocycles
Huang, Tiao,Kong, Dulin,Liu, Li,Wang, Qinghe,Wu, Mingshu
supporting information, p. 1387 - 1397 (2020/04/27)
An efficient stereoselective assembly st...
Synthesis and in vitro evaluation of neutral aryloximes as reactivators of Electrophorus eel acetylcholinesterase inhibited by NEMP, a VX surrogate
Cavalcante, Samir F. de A.,Kitagawa, Daniel A.S.,Rodrigues, Rafael B.,Bernardo, Leandro B.,da Silva, Thiago N.,dos Santos, Wellington V.,Correa, Ana Beatriz de A.,de Almeida, Joyce S.F.D.,Fran?a, Tanos C.C.,Ku?a, Kamil,Simas, Alessandro B.C.
, (2019/06/24)
Casualties caused by nerve agents, poten...
607-28-3 Process route
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-
91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione
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-
607-28-3,73859-64-0,73859-66-2
(E)-1H-indole-2,3-dione 3-oxime
| Conditions | Yield |
|---|---|
|
With
hydroxylamine;
In
methanol;
Reflux;
|
95%
|
|
With
hydroxylamine; acetic acid;
|
|
|
With
ethanol; water; hydroxylamine;
|
|
|
With
hydroxylamine hydrochloride; sodium acetate;
|
|
|
With
potassium hydroxide; hydroxylamine hydrochloride;
|
|
|
indole-2,3-dione;
With
hydroxylamine hydrochloride;
In
water;
for 0.5h;
Reflux;
With
sodium acetate;
In
water;
for 0.5h;
|
-
-
574-17-4
1-acetyl-1H-indole-2,3-dione
-
-
607-28-3,73859-64-0,73859-66-2
(E)-1H-indole-2,3-dione 3-oxime
| Conditions | Yield |
|---|---|
|
With
hydroxylamine;
In
ethanol;
for 3h;
Heating;
|
67%
|
607-28-3 Upstream products
-
59-48-3
2-oxoindole
-
42366-35-8
hydroxyimino-N-phenylacetamide
-
75-52-5
nitromethane
-
91-56-5
indole-2,3-dione
607-28-3 Downstream products
-
243-59-4
indophenazine
-
117069-75-7
3-aminoindolin-2-one
-
479-41-4
indirubin
-
1885-29-6
anthranilic acid nitrile
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