Triprolidine

  • CAS：486-12-4
  • purity：99%
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1.What is the Triprolidine ?

Antihistaminic.

2-(4-toluoyl)pyridine
78539-88-5

2-(4-toluoyl)pyridine

[2-(Pyrrolidin-1-yl)ethyl]triphenylphosphonium bromide

[2-(Pyrrolidin-1-yl)ethyl]triphenylphosphonium bromide

triprolidine
486-12-4,10191-42-1,13573-69-8

triprolidine

(Z)-triprolidine
13573-69-8

(Z)-triprolidine

Conditions
Conditions Yield
With potassium tert-butylate; In dichloromethane; at 10 ℃; for 3h;
With potassium tert-butylate; In dichloromethane; at 10 - 20 ℃; optical yield given as %de;
1-[2]pyridyl-3-pyrrolidino-1-<i>p</i>-tolyl-propan-1-ol
70708-28-0

1-[2]pyridyl-3-pyrrolidino-1-p -tolyl-propan-1-ol

triprolidine
486-12-4,10191-42-1,13573-69-8

triprolidine

Conditions
Conditions Yield
1-[2]pyridyl-3-pyrrolidino-1-p-tolyl-propan-1-ol; With sulfuric acid; In water; at 25 - 105 ℃;
With sodium hydroxide; In water; at 5 - 30 ℃; for 4h; Product distribution / selectivity;
82%

2.What is the CAS number for Triprolidine ?

The CAS number of Triprolidine is 486-12-4.

More information of Triprolidine 486-12-4 are:

CAS?Number

486-12-4

Density

1.061 g/cm3

Melting Point

59-61 °C

Boiling Point

435.4 °C at 760 mmHg

Flash Point

217.1 °C

Vapor Pressure

6.16E-09mmHg at 25°C

PSA

16.13000

LogP

3.85540

Pka

pKa 4.01(H2O t = 23.0) (Uncertain);9.69(H2O t = 23.0) (Uncertain)

3.What are another words for Triprolidine ?

Synonyms?for?Triprolidine 486-12-4:Pyridine,2-[(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]- (9CI);Pyridine,2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, (E)-;Pyridine,2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]-, (E)- (8CI);Triprolidin;Triprolidine;Tripyrolidine;trans-1-(2-Pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene;trans-1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene;trans-2-[3-(1-Pyrrolidinyl)-1-p-tolypropenyl]pyridine;

4.What is the molecular formula of Triprolidine?

The chemical formula of ?Triprolidine is?C19 H22 N2 which containing 19 Carbon atoms,22 Hydrogen atoms and 2 Nitrogen atoms,and the molecular weight of??Triprolidine?is 278.397.

5.What is Triprolidine (486-12-4) used for?

Triprolidine is an N-alkylpyrrolidine antihistamine, specifically acrivastine without the propenoic acid substituent on the pyridine ring. It is characterized by its sedating properties and is commonly used to alleviate symptoms of various conditions.

InChI:InChI=1/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;

Relevant articles related to Triprolidine:

Article

Source

A PROCESS FOR PREPARATION OF E-ISOMER OF 1-(4-METHYLPHENYL)- 1-(2-PYRID YL)-3-PYRROLIDINO PROP-1-ENE AND ACID ADDITION SALTS THEREOF

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Page/Page column 5; 9-10, (2009/08/14)

Use of a compound in providing refreshedness on waking and a method for the treatment of drowsiness therewith

-

, (2008/06/13)

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